PCSK9 Management for Hypercholesterolemia

Praluent® (alirocumab)

Description

Description

Praluent® is a human monoclonal antibody that inactivates a specific protein (PCSK9) in the liver. By knocking out the protein, this dramatically reduces LDL cholesterol in the blood stream. It is FDA approved as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease, who require additional lowering of LDL.

Dosing and Administration

Praluent® can be self-administered subcutaneously. The recommended dose for Praluent® is 75 to 150 mg every two weeks.

Common Side Effects

The most common side effects of PCSK9 inhibitor therapy include injection-site swelling, itching or rash, limb pain, fatigue, muscle pain and eye-related events. Some patients also reported memory problems, runny nose and sneezing, upper respiratory tract infection, flu symptoms and back pain.

Repatha® (evolocumab)

Description

Repatha® is a human monoclonal antibody that inactivates a specific protein (PCSK9) in the liver. By knocking out the protein, this dramatically reduces LDL cholesterol in the blood stream. It is FDA approved as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease, who require additional lowering of LDL and as an adjunct to diet and other LDL-lowering therapies (e.g., statins, ezetimibe, LDL apheresis) for the treatment of patients with homozygous familial hypercholesterolemia who require additional lowering of LDL.

Dosing and Administration

Repatha® can be self-administered subcutaneously. The recommended dose for Repatha® is 140 mg every 2 weeks or 420 mg every 4 weeks.

Common Side Effects

The most common side effects of PCSK9 inhibitor therapy include injection-site swelling, itching or rash, limb pain, fatigue, muscle pain and eye-related events. Some patients also reported memory problems, runny nose and sneezing, upper respiratory tract infection, flu symptoms and back pain.